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1 The actions of the potassium channel openers, cromakalim and minoxidil sulphate, were compared in a range of isolated blood vessel preparations. 2 Cromakalim and minoxidil sulphate inhibited spontaneous mechanical activity of the guinea-pig portal vein and relaxed the noradrenaline precontracted rat aorta with similar potency. In contrast, minoxidil sulphate was less potent than cromakalim in inhibiting spontaneous activity in the rat portal vein and was essentially inactive in the noradrenaline precontracted rat mesenteric artery and rabbit aorta. 3 Minoxidil sulphate did not antagonize the effects of cromakalim in the rabbit aorta indicating it was not acting as a partial 'agonist'. 4 Charybdotoxin, noxiustoxin and rubidium failed to discriminate between cromakalim and minoxidil sulphate indicating that the apparently selective effects of minoxidil sulphate were not mediated by either Ca(2+)-activated potassium channels, delayed rectifiers or rubidium impermeable potassium channels. 5 Glibenclamide antagonized the effects of cromakalim in an apparently competitive manner whereas the effects of minoxidil sulphate were antagonized in a non-competitive manner. The involvement of subtypes of ATP-sensitive potassium channels is discussed. PMID:1878752

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In certain applications, the nature of the classes makes manual training site delineation difficult, for example, an asphalt class consisting of narrow roads, or a water class for a river. In these cases, a semi-automated delineation is useful. Efficient tools have been developed that use region growing algorithms to define an irregular site, starting from a seed pixel specified by the analyst (Buchheim and Lillesand, 1989). The concepts behind region-growing algorithms are discussed in Sect

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where is independent of the underlying process and the measurement error vanishes as the intraday sampling frequency M increases. More generally, to make explicit distinction between different days, we rewrite this key equation as:

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